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Michelle Armstrong

Lab Group: Ted Holman

Department: Chemistry and Biochemistry

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Walter Bogdanoff

Lab Group: Rebecca Dubois

Department: Molecular Cell and Developmental Biology

Research Description: Human Astrovirus is a leading cause of severe gastroenteritis in young children and immunocompromised individuals. My project in the lab is to understand how the immune system recognizes and neutralizes astrovirus infection, and to use this information to develop an astrovirus vaccine. Part 1 of my project will be to use X-ray crystallography and biochemical assays to understand the molecular interactions between a virus-neutralizing antibody and the human astrovirus capsid protein. Part 2 of my project will be to engineer a protein-based astrovirus vaccine. Overall, these data will provide us with a better understanding of astrovirus infection and its prevention.

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Jaime Hernandez-Maldonado

Lab Group: Professor Chad Saltikov Lab

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