Talha Adil 

IMSD Junior

Lab Group: Grant Hartzog

Major: Biomolecular Engineering

Research: 

Isolation, purification and annotation of novel bacteriophage that have the ability to infect mycobacterium smegmatis. Attempting to elucidate various methods that may contribute to phage therapeutics as well as learning the arrangement of phage genes, their unique characteristics and their ability to combat potential diseases with a higher success and specificity than antibiotics.

Internships/Presentations/Awards:

Isolating Novel Bacteriophage R1R2. Talha Adil, Kevin Ekanem, Mario Escudurdo, Grant Hartzog. University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation

 
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Summer Research Experience 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016

Francis Albert Apolinario

IMSD Junior

Lab Group: Grant Hartzog

Major: Molecular, Cell, and Devleopmental Biology

Research: 

Spt 5 is tightly associated with RNA polymerase II during transcription elongation.  Mutations in Spt5 effect RNA polymerase II processivity and translocation rate.  Evidence shows Spt4/5 are involved in overcoming nucleosome barriers and remodeling chromatin during elongation.  Our research specifically focuses on the C Terminal Repeats of Spt5.  Low Complexity sequences have prion like properties and are known to have multiple conformations and bind to different proteins.  Low complexity sequences are known to be present in the C terminal repeats of the Spt 5 protein.  We are currently looking for proteins that bind to the different conformation states of the C Terminal Repeats and how they affect transcription elongation.  

Internships/Presentations/Awards:

Investigating The Structural Properties of Plasmid DNAInvestigating The Structural Properties of Plasmid DNA. Francis Albert Apolinario, Erik Li, and Michael D. Stone. University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation.  

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2016 SACNAS National Conference, Travel Scholarship Recipient. 

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Summer Research Institute 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016

Fidel Arizaga

IMSD Junior

Lab Group: William Saxton 

Major: Biochemistry and Molecular Biology

Research: 

Understanding the mechanism and purpose of the motor protein Kinesin-1 autoregulation and it's neurodegenerative effects using the Drosophila model system

Internships/Presentations/Awards:

Identification of Wolbachia bacteria in wild Drosophila and the applications to human health. Fidel Arizaga, Reyna Montoya, Diana Tamayo, and William Sullivan, University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation.                                                                                                                                                                    

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2016 SACNAS National Conference, Travel Scholarship Recipient

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Summer Research Institute 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016


Nathan Bamidele

IMSD Junior

Lab Group: Jeremy Sanford 

Major: Molecular, Cell, and Developmental Biology

Research: 

Researching the common mechanistic impacts of single nucleotide substitutions on Pre-mRNA splicing. In addition to testing whether different genetic diseases are linked by these common aberrant splicing mechanisms. 

Internships/Presentations/Awards:

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Research and Development Assitant, 2012, Biocare Medical 
 

Anthony Del Cid

IMSD Senior

Lab GroupPradip Mascharak

Major: Neuroscience

Research:

Silver ion loaded, polymer-based dressings and their applications for wound care: 

Due to the rise in antibacterial drug resistance, alternative therapeutics are on a rise. Silver is historically one of the oldest antimicrobials, with multidirectional avenues of bacterial offense that make it difficult to develop resistance against. We encapsulate silver ions in a polymer based system, whose own properties inherently optimizes the wound healing process, with a Imidazole-Dansyl per chlorate ligand (synthesized in the Mascharak lab). Our dressing is capable of providing a steady release rate of silver ions at antibacterial concentrations. In addition, providing reporter Dansyl groups to this particular ligand, the Mascharak group provides release of silver at rates that can be tracked, ensuring proper silver ion release. 

Peroxynitrite and its role in inflammation related diseases:

Peroxynitrite (PN) is both a nitrating and oxidative reactive species, linked to many chronic diseases including: diabetes, cancer, and neurodegenerative diseases. The Mascharak group has synthesized a photo-activated multi-well platform that reacts PN precursors to produce PN at concentrations readily available for characterization. We are currently characterizing byproducts of PN produced when in proximity to anti-inflammatory drugs and there relative implications. 

Presentations/Awards/Internships:

Rhenium Tricarbonyl Complexes incorporating a-diimine ligands, a novel framework for Bioimaging. Anthony Del Cid, Jorge Jimenez, Indranil Chakraborty, and Pradip Mascharak, University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation.

Is the Increased Virulence of LasA Protease Mutants Due to Increased Expression of LasB Protease?  Anthony Del Cid, Aaron Sullivan, Suzanne Fleiszig. University of California,Santa Cruz, 6th Annual Physical and Biological Sciences Summer Research Symposium, 2015. Poster Presentation.

The Challenges Antibiotic Resistant Bacteria Pose: E. Coli Growth in the Presence of Ampicillin and Kanamycin. Anthony Del Cid, Anh Nguyen, and Carolina Zamora with Victoria Auerbuch Stone in the Summer Research Institute. University of California, Santa Cruz. 5th Annual Physical and Biological Sciences Summer Research Symposium, 2014. Poster Presentation.

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Summer Research Experience 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016

Maximizing Access to Research Career (MARC) Scholar, University of California, Santa Cruz, CA. 2014-2016

Summer Research Institute 2014, University of California-Santa Cruz, Santa Cruz, CA. Summer 2014 


Jocelyn Delgado

IMSD Junior

Lab Group: Vicki Auerbuch Stone

Major: Molecular, Cell, and Developmental Biology

Research: 

I work with graduate student mentor on inhibition of the bacterial type three secretion system (T3SS) in Yersinia. The purpose of our project is to identify novel inhibitors of the T3SS and begin to characterize their activity. The T3SS is a key virulence factor to dozens of pathogens including the causative agents of the black plague. Our work is critical, as it may contribute to a solution for one of the most troubling medical necessities of the present time; antibiotic resistance. 

Internships/Presentations/Awards:

Antibiotic Resistance in Escerichia Coli. Jocelyn Delgado, Cristian Diaz. Daysy Guzman, Victoria Auerbuch Stone. University of Californa, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposioum, 2016. Poster Presentation

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2016 SACNAS National Conference, Travel Scholarship Recipient

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Summer Research Institute 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016


Annmarie Domingue

IMSD Junior

Lab Group:

Major: Chemistry

Research:

 

Internships/Presentations/Awards:


 


Kevin Ekanem

IMSD Junior

Lab Group: Grant Hartzog

Major: Molecular, Cell, and Developmental Biology 

Research: 

Bacteriophage, viruses that infect bacteria, are the most numerous organisms and one of the greatest sources of genetic diversity on the planet. With greater than 1000 sequenced genomes available, mycobacteriophage, which infect mycobacteria, are the best-characterized class of bacteriophages. Comparison of these genomes has shown that each mycobacteriophage is unique and that the mycobacteriophages frequently exchange small portions of their genomes with their hosts and other mycobacteriophage. This extensive exchange prevents construction of conventional phylogenies but mycobacteriophage with similar genomic structures can be grouped in one of 27 clusters. We are studying Violet; a mycobacteriophage isolated at UCSC that is a member of cluster A1. Interestingly, gp57 of Violet is encoded by a 1.5kb nucleotide sequence that appears to be completely unique to the A1 cluster. A BLASTx search showed that this sequence has the potential to encode protein in two different reading frames. The first appears to encode a protein whose N- and C-termini resemble a DNA methyltransferase and whose central region is unique. The second reading frame, which roughly overlaps the unique domain in the first open reading frame, encodes an HNH nuclease. Interestingly, mass-spectrometry of phage Violet suggests that both reading frames are expressed. We will discuss hypotheses and strategies to explain the genesis and functions of this interesting gene.

Internships/Presentations/Awards:

Protein Expression from Overlapping Reading Frames od Mycobacteriophage Violet. Keving Ekanem and Grant Hartzog, University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation

Comparative Genomics of Cluster O Mycobacteriophages. PLoS ONE 10(3). 2015. Publication.

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Koret Undergraduate Research Scholarship Recipient 2017

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Summer Research Experience 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016
 

Edgar Esparza

IMSD Junior

Lab Group: Lindsay Hinck

Major: Molecular, Cell, and Developmental Biology

Research: 


Internships/Presentations/Awards:

 

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Carmen Ma

IMSD Junior

Lab Group: Susan Strome

Major: Molecular, Cell, and Developmental Biology

Research: 

Development occurs through transcription factors and epigenetics, which includes post translational histone modifications that bookmark certain genes to be passed down from mother to offspring. In C. elegans, MES-4, a histone methyltransferase, confers germline potential for proper germline viability. However, previous evidence confirms that intestinal tissue (somatic cells) contains germline potential but is repressed by DRM complex in order to keep its somatic programming. If MES-4 is present in intestinal tissue, perhaps it is also in other somatic tissues. My project analyzes MES-4 localization using live imaging and immunostaining all larval stages of C. elegans. My project will answer if MES-4 is present in other somatic tissues and contribute to the bigger question of the lab: How does development proceed?

Internships/Presentations/Awards:

Effects of different long-chain saturated fatty acids on obesity-linked inflammation and metabolic disorders. Carmen Ma, Curtis Perriotte-Olson, Gopalakrishnan Natarajan, and Saraswathi Viswanathan. University of Nebraska Medical Center, Department of Internal Medicine Poster Session, Summer 2016, Poster Presentation.

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Summer Undergraduate Research Program (SURP) at University of Nebraska Medical Center (UNMC), Division of Diabetes, Endocrinology & Metabolism, Summer 2016
 

Jethro Marasigan

IMSD Junior

Lab Group: David Hassuler

Major: Molecular, Cell, and Developmental Biology

Research: 

The broad spectrum of long non-coding RNAs (lncRNA) functionality ranges from genomic site specific epigenetic reprogramming to subcellular structural organization playing a crucial role in biological processes such as development and differentiation. However, with only a fraction out of thousands being tested for functionality, lncRNAs lack in proper annotation. LncRNAs spatial and temporal specific expression makes them a challenging target for molecular biologist but is indicative of their vast potential in regulation and more interestingly, speciation. In the Haussler lab, we have discovered human specific lncRNAs that are expressed in the early development of neurogenesis. We hypothesize that these lncRNAs slow down neuronal differentiation resulting in an increase of brain size in comparison to mammals, such as primates, that do not express these lncRNA. My research focuses on isolating and annotating the novel lncRNA expressed at week 2 of neuronal differentiation.  

Internships/Presentations/Awards:

2016 Spring Dean's Award

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Maximillian Marin

IMSD Senior

Lab Group: Angela Brooks 

Major: Biochemistry and Molecular Biology

Research:


Internships/Presentations/Awards:

Analyzing epistasis between mutations in a Saccharomyce cerevisiae promotor. University of California, Santa Cruz, ACE Orientation and Resource Fair, 2016. Poster Presentation

Analyzing epistasis between mutations in a Saccharomyce cerevisiae promotor.  University of Washington, Undergraduate Reseach Summer Symposium, 2016. Poster Presentation  

High-thoughtout functional screen of skipped exons contributing to lung cancer development. University of California, Santa Cruz. 7th Annual Physical and Biological Science Summer Research Symposium, 2016. Poster Presentation

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2016 SACNAS National Conference, Travel Scholarship Recipient

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Seven Bridges Hackathon. 2016

Howard Hughes Medical Insititute Exceptional Research Opportunity Program, University of Washington. Summer 2016

Broad Institude Summer Research Program in Genomics, Broad Institute's Center. Summer 2015


Hector Navarro

IMSD Senior

Lab Group: William Sullivan

Major: Molecular, Cell, and Developmental Biology

Research: 


Internships/Presentations/Awards:

How Do Mitotic Cells Deal With Broken Chromosomes? Hector Navarro, Brandt Warecki, and William Sullivan, University of California,Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2015. Poster Presentation.

How Do Broken Chromosomes Segregate? Hector Navarro, Brandt Warecki, William Sullivan. University of California, Santa Cruz. 6th Annual Physical and Biological Sciences Summer Research Symposium, 2015. Poster Presentation.

Featured as an undergraduate researcher in UCSC's newsletter in an article by Peggy Townsend. 
 
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Summer Research Experience 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016
 
Summer Research Experience 2015, University of California Santa Cruz. Santa Cruz, CA. Summer 2015
 

Theron Palmer

IMSD Senior

Lab Group: Christopher Vollmers

Major: Bioelectronics

Research:


Internships/Presentations/Awards:

Comparative Genomic Analysis of Human Naïve and Memory B-Cell Immunoglobulin Switch Regions. Theron Palmer, Roger Volden, Henry Hinton, Chris Vollmers. University of California,Santa Cruz, 6th Annual Physical and Biological Sciences Summer Research Symposium, 2015. Poster Presentation.

 
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Summer Research Experience 2015, University of California Santa Cruz. Santa Cruz, CA. Summer 2015
 

Ivette Perez

IMSD Senior

Lab Group: Carrie Partch

Major: Biochemistry and Molecular Biology

Research: 


Internships/Presentations/Awards:

Investigating the role of CLOCK Exon 19 in Regulating the CLOCK:BMAL1 Transcriptional Activity in the Mammalian Circadian clock. University of California, Irvine. California Alliance for Minority Participation (CAMP) Conference, 2017. Poster Presentation. 

Investigating the role of CLOCK Exon 19 in Regulating the CLOCK:BMAL1 Transcriptional Activity in the Mammalian Circadian clock. Tampa, FL. Annual Biomedical Research Conference for Minority Students (ABRCMS), 2016. Poster Presentation. 

Investigating the role of CLOCK Exon 19 in Regulating the CLOCK:BMAL1 Transcriptional Activity in the Mammalian Circadian clock. University of California, Santa Cruz, 7th Annual Physical and Biological Science Summer Research Symposium, 2016. Poster Presentation

The Roles of the Greatwall Kinase in Acentric Chromosome Segregation. University of California, Santa Cruz, Division of Physical and Biological Sciences and Jack Basking Engineering 18th Annual Undergraduate Research Symposium, 2016. Poster Presentation.

Finding Potent Wolbachia Strain to Deter Viral Infection in Mosquitoes. University of California, Santa Cruz, 6th Annual Physical and Biological Sciences Summer Research Symposium, Summer 2015. Poster Presentation.

Finding Potent Wolbachia Strain to Deter Viral Infection in Mosquitoes. Hartnell Poster Symposium, The 9th Annual STEM Internship Symposium, Summer 2016. Poster Presentation

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Special Merit Award, CAMP Conference, February 2017

Koret Undergradute Research Scholarship, Winter 2017

Dean’s Award, UC Santa Cruz, Winter 2016

SACNAS Travel Scholarship, Summer 2015

Pando Family Scholarship, Hartnell Community College Summer 2015

President’s List, Hartnell Community College Spring 2015

President’s List, Hartnell Community College Fall 2014

Recipient of WELI Scholarship, Hartnell Community College Spring 2014

NSF Scholar, Hartnell Community College Spring 2012-Spring 2014

Hartnell’s Women Soccer Team Coach’s Award, Hartnell Community College Fall 2012

Dean’s List, Hartnell Community College Fall 2011-Spring 2014

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Summer Research Experience 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016

Summer Research Institute 2015, University of California Santa Cruz. Santa Cruz, CA. Summer 2015

ACCESS Mini Winter Research Camp, UC Santa Cruz, Winter 2015

ACCESS Lab Tour, UC Santa Cruz, Spring 2014

WELI Leadership and Life Skills Workshops, Hartnell Community College, Summer 2014
 

Edmundo Perez

IMSD Senior

Lab Group: Rebecca Dubois

Major: Biomolecular Engineering

Research: 

Lab focuses on the Human astrovirus and its role in cell infectivity and structural importance. Through the use of protein engineering and X ray crystallography we gain further knowledge how the structure mediates infection.

Internships/Presentations/Awards:

Functional Studies on a Human Astrovirus-Neutralizing Antibody. University of California-Santa Cruz, 7th Annual Physical and Biological Science Summer Research Symposium, 2016. Poster Presentation.

Functional Studies on a Human Astrovirus-Neutralizing Antibody. Hartnell Community College, Hartnell Poster Symposium, 2016. Poster Presentation.

Functional Studies on a Human Astrovirus-Neutralizing Antibody. University Of Irvine. California Alliance for Minority Participation (CAMP) Conference, 2016. Poster Presentation and Honorable Mention Award 

Functional Studies on a Human Astrovirus-Neutralizing Antibody, Washington, D.C. Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS), 2015. Poster Presentation.

Functional Studies on a Human Astrovirus-Neutralizing Antibody. University of California-Santa Cruz, 6th Annual Physical and Biological Science Summer Research Symposium, 2015. Poster Presentation.

Functional Studies on a Human Astrovirus-Neutralizing Antibody. Hartnell Community College, Hartnell Poster Symposium, 2015. Poster Presentation.

Surface Modification of Solid State Nanopores vis Early Development of a Saccharde Sensor. University of California-Santa Cruz, 5th Annual Physical and Biological Science Summer Research Symposium, 2014. Poster Presentation

Surface Modification of Solid State Nanopores vis Early Development of a Saccharde Sensor. Hartnell Community College, Hartnell Poster Symposium, 2014. Poster Presentation.

Surface Modification of Solid State Nanopores vis Early Development of a Saccharde Sensor. The 7th Annual STEM internship Symposium, Salinas, Summer 14. Poster Presentation

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Dean’s Award, UC Santa Cruz Spring 2016

Dean’s Award, UC Santa Cruz Winter 2016

SACNAS Travel Scholarship, Summer 2015

Hartnell Community College Summer Scholarship 2015

President’s List, Hartnell Community College Spring 2015

President’s List, Hartnell Community College Fall 2014

Dean’s List, Hartnell Community College Fall 2011-Spring 2014

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Summer Research Experience 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016
 
California Alliance for Minority Participation (CAMP), UC Santa Cruz, 2015-16
 
Summer Research Experience 2015, UC Santa Cruz, Summer 2015

ACCESS Summer Research Institute, UC Santa Cruz, Summer 2014
 

Joanna Perez

IMSD Senior

Lab Group: Nader Pourmand

Major: Molecular, Cell, and Developmental Biology

Research: 

The Pourmand Lab is a lead researcher in Biosensors and Biotechnology at UCSC.  The lab focuses in nanopipette technology for the use of biosensors, which hold great potential for understanding single cell biology, and as a result an advancement in cancer- research, stem cell research and research involving neurodegenerative diseases.

Internships/Presentations/Awards:

Quartz Nanopipette for Intracellular Superoxide Sensing. University of California, Irvine. California Alliance for Minority Participation (CAMP) Conference, 2016, Poster Presentation.

Quartz Nanopipette for Intracellular Superoxide Sensing. Washington D.C. Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) Conference, 2015. Poster Presentation.

Cloning of a SPT5 Fragment using Molecular Cloning Techniques. University of California, Santa Cruz, 5th Annual Physical and Biological Sciences Summer Undergraduate Research Symposium,  2014. Poster Presentation.

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2016 Chancellor’s Achievement Awards for Diversity for her work done with SACNAS and other organizations at UCSC, Spring 2016

2016 Dean’s Award for her research project on "Quartz Nanopipette for intracellular Superoxide Sensing." Spring 2016

CAMP-NSF Symposium Honorable Mention for her work on "Quartz Nanopipette for intracellular Superoxide Sensing." Winter 2016

2015 and 2014 SACNAS (Society for the Advancement of Chicanos/Hispanics and Native Americans in the Sciences) National Conference - Travel Scholarship Award Recipient

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Summer Research Experience 2015, University of California Santa Cruz. Santa Cruz, CA. Summer 2015
 
Summer Research Insititute 2014, University of California Santa Cruz. Santa Cruz, CA. Summer 2014
 

Nancy Sanchez

IMSD Senior

Lab Group: Grant Hartzog

Major: Molecular, Cell, and Development Biology

Research: 

During transcription elongation, accessory proteins help RNA Polymerase II transcribe through a gene by removing and reassembling physical protein barriers—nucleosomes. One accessory factor, Spt5, is a universally conserved transcription elongation factor that is essential for life in all eukaryotes. We study Spt5 in Saccharomyces cerevisiae because it is a genetically tractable model eukaryote whose gene expression machinery is closely similar to that in humans. Our focus is understanding the role Spt5 plays in chromatin dynamics during transcription elongation. Currently, my project focuses on determining the function of an uncharacterized region in Spt5.

Internships/Presentations/Awards:

Gonadal Control of Male Sexual Behavior in Drosophila. Sanchez N, S Herrera, with Professor Erika Bach. Stamford, CT. The Leadership Alliance National Symposium 2016. Oral Presentation

Characterization of spt5 Mutations in Saccharomyces cerevisiae that Cause Cryptic Initiation. Sanchez N, M Doody, with Professor Grant Hartzog. Tampa, FL. Annual Biomedical Research Conference for Minority Students (ABRCMS), 2016.

Characterization of spt5 Mutations in Saccharomyces cerevisiae that Cause Cryptic Initiation. Sanchez N, M Doody, with Professor Grant Hartzog. Long Beach, CA. Society for the Advancement of Chicanos/Hispanics and Native Americans in Science National (SACNAS) Conference, 2016. Poster Presentation

Gonadal Control of Male Sexual Behavior in Drosophila. Sanchez N, S Herrera, with Professor Erika BachNew York University. Summer Undergraduate Research Program, 2016. Poster Presentation 

Characterization of spt5 Mutations in Saccharomyces cerevisiae that Cause Cryptic Initiation. Sanchez N, M Doody, with Professor Grant Hartzog. University of California, Santa Cruz. 19th Annual Undergraduate Research Poster Symposium, 2016. Poster Presentation

Characterization of spt5 Mutations in Saccharomyces cerevisiae that Cause Cryptic Initiation. Sanchez N, M Doody, with Professor Grant Hartzog. University of California, Irvine. California Alliance for Minority Participation Statewide conference (CAMP) Conferece, 2016. Poster Presentation

Structural Analysis of pUC19 in NEB 5-alpha Competent E. coli Cells Treated with BamHI and Topoisomerase I Enzymes. Nancy Sanchez, Daniela Bolaños, Shankar Shastry with Professor Michael D. Stone. University of California, Santa Cruz. 5th Annual Physical and Biological Sciences Summer Research Symposium, 2015. Poster Presentation.

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2016 SACNAS National Conference Travel Scholarship 

2016 Hispanic Scholarship Fund Scholar 

2016 Winter Dean’s Honors

2016 Honorary Mention CAMP-NSF Symposium – University of California-Irvine 

2014, 2015 District Council of Ironworkers Scholarship 

2013 Charles and David Pettigrew Scholarship

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New York University Summer Undergraduate Research Program 2016, NYU Langone Medical Center, Summer 2016

Summer Research Institute 2015, University of California Santa Cruz. Santa Cruz, CA. Summer 2015
 

Dominic Schenone

IMSD Senior

Lab Group: Angela Brooks

Major: Bioengineering and Electrical Engineering

Research:


Internships/Presentations/Awards:

The Design and Overexpression of Aldehyde/Alcohol Dehydrogenase Genes in Haloferax Volcanii: For the Conversion of Butyryl-CoA to Butanol.   Dominic Schenone, Jazel Hernandez, Alonzo Lee, Sanusha Bijj, Derek Brekke, Jackson DeKloe, Vijay Jayant, Megana Kunda, Isabel Madau, Kendal Prokopakis, David Bernick. University of California, Santa Cruz, 6th Annual Physical and Biological Sciences Summer Research Symposium, 2015. Poster Presentation. 

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Summer Research Experience 2015, University of California Santa Cruz. Santa Cruz, CA. Summer 2015
 

Kelssie Sontay

IMSD Junior

Lab Group: Jordan Ward

Major: Human Biology

Research: 

 

Internships/Presentations/Awards:

Improving Efficiency of Isolation of Chromosome Circles. Kelssie Sontay, Carolina Cuellar and Grant Hartzog, University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation 

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Summer Research Insititute 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016
 

Michael Yxcot

IMSD Senior

Lab Group: Michael Stone

Major: Biochemistry and Molecular Biology

Research:

Telomerase is an essential ribonucleoprotein responsible for maintaining telomeres, which are the protective caps at the ends of linear chromosomes that prevent genomic degradation. Understanding the complex structure and function of the telomerase holoenzyme is vital to combating diseases such as dyskeratosis congenita and cancer, which highjack this highly regulated biological machine. Tetrahymena telomerase is composed of a protein component (tTERT) as well as an integral RNA component (tTER). tTER is composed of several conserved regions including the template region which telomeres get reverse transcribed off of, a distal stem/loop (Stem I/IV), a template boundary element (Stem II), and a pseudoknot domain. These domains are all essential for proper telomerase activity and are well conserved across species. How TER and TERT interact to form a functional unit is not well understood. In order to better understand the structural basis for the TER/TERT interactions, I will investigate how the RNA-Binding Domain (RBD) of tTERT interacts with tTER. Recently in the lab, a structure of the TetrahymenaRBD/Stem II complex was solved using X-ray crystallography. Here, I want to further utilize this construct to compile more of tTER to ultimately gain a better understanding of the telomerase holoenzyme. Furthermore, I will form complexes of RDB with different Stem IV, Stem I-IV and Stem I/II/IV constructs with the goals of probing these complexes using X-ray crystallography. Structural definition of the Tetrahymena telomerase catalytic core will lead to a better model of the human enzyme by providing insight into conserved TER/TERT interactions.

Internships/Presentations/Awards:

Understanding the Tetrahymena Thermophila Telomerase Structure: One Construct at a Time. Michael Yxcot, Linnea Jannson, and Michael Stone. Summer Research Experience. University of California-Santa Cruz, Summer Research Symposium, 2016. Poster Presentation.

Understanding the Tetrahymena Thermophila Telomerase Structure: One Construct at a Time. Michael Yxcot, Linnea Jannson, and Michael Stone. University of California-Santa Cruz, Undergraduate Research Poster Symposium, 2016. Poster Presentation

Finding Potent Wolbachia Strains to Deter Viral Infection in Mosquitoes. Michael Yxcot,  and Ivette Perez with Professor William Sullivan in the Summer Research Institute. University of California-Santa Cruz, Summer Research Symposium, 2015. Poster Presentation.

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Summer Research Experience 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016

Summer Research Insititute 2015, University of California Santa Cruz. Santa Cruz, CA. Summer 2015

 

Leonel Torres

IMSD Junior

Lab Group:

Major: Human Biology

Research: 


Internships/Presentations/Awards:

Control of Membrane Growth and Cell Size. Leonel Torres, Robert Sommer, Doug Kellogg. University of California, Santa Cruz. 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation.

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Summer Research Experience 2016, University of California Santa Cruz. Santa Cruz, CA. Summer 2016
 
copyright of University of California 2011