Shannon Renee Barbour

MARC Graduate-Class of 2015. Transferred from Monterey Peninsula Community College

Lab Group: Ted Holman Lab

Major: Molecular, Cell, and Development Biology

Research: I am studying the kinetics of the enzyme lipoxygenase and its role in the inflammatory response.

Publications: Smyrniotis, C.J., Barbour, S.R., Xia, Z., Hixon, M.S., Holman, T.R. (2014). ATP allosterically activates the human 5-lipoxygenase molecular mechanism of both arachadonic acid and 5(S)-HpETE. Biochemistry. 53(27), 4407-19.

Presentations/Awards/Internships:

An evolutionary arms race between endogenous retrotransposons and their restriction factors. Barbour, S.R., McLaughlin, R.N., Malik, H.S. University of Washington, Seattle, WA. Annual Biomedical Research Conference for Minority Students (ABRCMS), San Antonio, TX. November 2014. Poster Presentation.

An evolutionary arms race between endogenous retrotransposons and their restriction factors. Barbour, S.R., McLaughlin, R.N., Malik, H.S. University of Washington, Seattle, WA. Poster presentation delivered at the Summer Undergraduate Research Symposium at the Fred Hutchinson Cancer Research Center, Seattle, WA. August 2014. Poster Presentation.

Analysis of T Cell Development: Effect of Transgenic TCR During Double Negative Stages. Shannon Barbour, Lennard Dalit, Nick Fong, and Becca Laplante with Profressor Martha Zuniga in the Summer Research Institute. University of California-Santa Cruz, UndergraduateSummer Research Symposium, 2013. Poster Presentation.

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ABRCMS National Poster Presentation Award, Developmental Biology and Genetics Research Division (2014)

UCSC Tony Fink Memorial Student Award 2014

Howard Hughes Medical Institute (HHMI) Exceptional Research Opportunity Program scholar. Award provides funding for an initial summer internship and capstone summer internship at a HHMI lab. 2014-2015

UCSC NIH-Maximizing Access for Research Careers (MARC) Fellow 2013-2015

Pister Leadership Scholarship (UCSC)-May 2013

American Chemical Society Scholarship (ACS)-May 2013

American Association of University Women (private foundation)-May 2013

Edith Brodie Eyres Memorial Scholarship (private foundation)-May 2013 

Heritage Memorial Scholarship (private foundation)-May 2013

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Summer Undergraduate Research Program (SURP). Fred Hutchinson Cancer Center, Seattle, WA. June 2014 - August 2014.

Summer Research Institute 2013. University of California-Santa Cruz, Santa Cruz, CA. Summer 2013


Adan Codina

MARC Graduate-Class of 2015.

Lab Group: Dr. Bill Sullivan Lab

Major: Molecular, Cell, and Developmental Biology

Research: Investigating the intracellular bacteria, Wolbachia, and its host pathogen interactions

Presentations/Awards/Internships:

Mitochondrial Protective Peptide SS-31 Reverses Cardiac Aging in Mice. Adan Codina, Ying Ann Chiao, and Dr. Peter Rabinovitch. University of Washington, Seattle, WA. Annual Biomedical Research Conference for Minority Students (ABRCMS). San Antonio, TX. November 2014. Poster Presentation.

Drugs Are Becoming Less Effective: The Rise of Antibiotic Resistance. Adan Codina and Lennard Dalit with Professor Victoria Auerbach Stone in the Summer Reseasrch Institute. University of California-Santa Cruz, Santa Cruz, CA. Undergraduate Summer Research Symposium 2013, University of California-Santa Cruz, Santa Cruz, CA. August 2013. Poster Presentation.

Testing for the Presence of Wolbachia Strains in Big Creek Arthropods. Adan Codina and Carlos Gonzalez with Professor William Sullivan in the Summer Research InstituteUniversity of California-Santa Cruz, Santa Cruz, CA. Undergraduate Summer Research Symposium 2013, University of California-Santa Cruz, Santa Cruz, CA. August 2013. Poster Presentation.

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2014 UW Agmen Scholar Program. University of Washington, Seattle, WA. Summer 2014

Summer Research Institute, University of California-Santa Cruz, Santa Cruz, CA. Summer 2013

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ABRCMS Poster Presentation Winner. November 2014


Yongtong Lao

MARC Graduate - Class of 2017

Lab Group: Scott Lokey

Major: Molecular, Cell & Developmental Biology

Research:

Synthetic analogs of cyclic peptide Phepropeptin as virulence blockers of human pathogens

Gram-negative pathogens cause millions of illnesses and death worldwide each year. Treatment of infections with antibiotics, which target all bacteria indistinguishably, often gives rise to resistance and destroys our healthy microbiota. Emergence of antibiotic resistance bacteria is the current issue of global public health. One promising strategy to combat the antibiotic resistant bacteria is virulence blockers, which are compounds that suppress pathogenicity without killing or inhibiting bacterial growth. Type III secretion system (T3SS), a needle-like appendage that bacteria use to inject effector proteins to the host cells to suppress host defense is an important virulence factor target for drug development. T3SS is required for virulence in dozens of Gram-negative bacteria pathogens but largely absent in nonpathogenic bacteria. We identified analogs of the natural cyclic peptide Phepropeptin that inhibit T3SS in both Yersinia and Pseudomonas through an innate immune-based high throughput screen. To further optimize the efficacy, we synthesized new analogs with improved potency. The best compound from this series inhibits 90% of toxin excretion and has an IC50 of 4 mM. These peptides did not inhibit bacterial growth and did not target flagellum, a motility system structurally similar to T3SS, indicating a specific block on the T3SS. Therefore, analogs of Phepropeptin are promising virulent blockers of several human pathogens.

Presentations/Awards/Internships:

Optimization of Novel Type III secretion inhibitors as Anti-virulence Factor. Yongtong Lao, Joshua Schwochert, Hanh Lam, Scott Lokey and Vicki Auerbuch Stone. Long Beach, CA. Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) Conference, 2016. Poster Presentation.

Synthetic analogs of cyclic peptide Phepropeptin as virulence blockers of human pathogen. Yongtong Lao, Joshua Schwochert, Joshua Schwochert, Hanh Lam, Vicki A. Stone, and Scott Lokey, University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation

Synthetic Peptoid  Analogs  of Phepropeptin  Inhibit  Bacterial  Type  III Secretion System. Yongtong Lao, Joshua Schwochert, Hanh Lam, Scott Lokey and Vicki Auerbuch Stone. University of California, Santa Cruz. Division of Physical and Biological Science and Jack Baskin Engineering 19th Annual Undergraduate Research Symposium, 2016. Poster Presentation 

Synthetic Peptoid Analogs of Phepropeptin Inhibit Bacterial Type III Secretion System. Yongtong Lao, Joshua Schwochert, Hanh Lam, Scott Lokey and Vicki Auerbuch Stone. University of California,Santa Cruz. Department of Chemistry Bunnett Research Symposium, 2016. Poster Presentaion.

1.Schwochert,  J. A.; Lao,Y.; Rye, C. R.; Naylor, M.R.; Desai, PV.; Gonzalez Valcarcel,  IC.; Barrett, JA.; Sawada, G.; Blanco, MJ and  Lokey, R.S. JAS Medicinal  Chemistry  Letters, 2016. Stereochemistry  balances cell permeability  and solubility  in thenaturally derived phepropeptin cyclic peptides. 2016  

2.Pye, R.; Hewitt, W.; Schwochert, J. A.; Haddad, T.; Townsend, C .; Etienne, L.; Lao, Y.;  Limberakis,  C.; Furukawa,  A.; Mathiowetz,  A.; Price, D.; Liras, L and Lokey, R.S. Non-Classical  Size Dependence of Permeation Defines Bounds for Passive Adsorptionof Large Drug Molecules. 2016  

Manuscript in Prep
1. Lam, H.; Schwochert, J. A; Lao, Y.; Kooner, O.; Luu, J.; Morgan, J.; Lokey, R.S and Auerbuch, V. Synthetic  Cyclic Peptomers As Type III Secretion System Inhibitors. 2017
 
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2013-2016 Dean’s honors  
 
2016 SACNAS (Advancing Chicanos/Hispanic & Native Americans in Science) Travel Scholarship 
 

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Summer Research Experience 2016, University of California, Santa Cruz. Santa Cruz, CA. Summer 2016


Britney Martinez

MARC Graduate-Class of 2015.

Lab Group: Professor Manny Ares Lab

Major: Molecular, Cell, and Developmental Biology 

Research: Alternative RNA Splicing Mechanisms

High-Throughput Screen to Identify Replication Origin Enhancers in Yeast, University of Washington Summer Research Poster Session. August 2013. Seattle, WA.

Understanding the Mechanism of MER 1 Activated Splicing, UC Santa Cruz Undergraduate Research Symposium. June 2013.

Presentations/Awards/Internships:

Purification of Splicing Proteins, Including Mer1, to identify Sequences They Interact With Authors: Britney Martinez, Manny Ares, PhD UCSC Summer 2014. Poster Presentation

High Troughput Screen to Identify Replication Origing Enhancers in Yeast Authors: Britney Martinez, Ivan Liachko, Kelsey Lynch and Maitreya Dunham University of Washington Summer 2013. Poster Presentation

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RMI- Research Mentoring institute with Zia for participating in Research involving genetics

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Summer Research Experience 2014, University of California, Santa Cruz, CA, Summer 2014.

University of Washington Genome Sciences Summer Program, University of Washington, Seattle, WA. Summer 2013


Steven Paniagua

MARC Graduate-Class of 2015.

Lab Group: Professor Bill Saxton

Major: Biochemistry and Molecular Biology

Research: My project is investigating how Klc and Milton may be involved in streaming. I am observing the effects of Klc and Milton inhibition on ooplasmic streaming through use of time lapse confocal microscopy. This was done by quantifying the velocity of fluorescent yolk endosomes during streaming in oocytes in which Klc or Milton or both were knocked down by RNAi.

Presentations/Awards/Internships:

Hepatic Gene Expression Analysis of Nuclear Receptor Subfamily 0, Group B, Member 2 (Nr0b2) in Type 2 Diabetic Mice, TALLYHO. Steven Paniagua, Jung Han Kim. Marshall University, Huntington, WV. Annual Biomedical Research Conference for Minority Students. San Antonio, TX. November 2014. Poster Presentation.

Hepatic Gene Expression Analysis of Nuclear Receptor Subfamily 0, Group B, Member 2 (Nr0b2) in Type 2 Diabetic Mice, TALLYHO. Steven Paniagua, Jung Han Kim. Marshall University, WV. Summer 2014. Poster Presentation.

Understanding Why Proteins That Connect Kinesin-1 to Cargoes are Important during Drosophila Oogenesis. Steven Paniagua, Donna Fullerton, William M. Saxton. University of California-Santa Cruz, Santa Cruz, CA. Annual Biomedical Research Conference for Minority Student, Nashville, TN, 2013. Poster Presentation.

Understanding Why Proteins That Connect Kinesin-1 to Cargoes are Important during Drosophila Oogenesis. Steven Paniagua, Donna Fullerton, William M. Saxton. University of California-Santa Cruz, Santa Cruz, CA. CAMP Statewide Conference, UC Irvine, California, February 2014. Poster Presentation.

Understanding Why Proteins That Connect Kinesin-1 to Cargoes are Important during Drosophila Oogenesis. Steven Paniagua, Donna Fullerton, William M. Saxton. University of California-Santa Cruz, Santa Cruz, CA. Undergraduate Summer Research Symposium 2013, University of California-Santa Cruz, Santa Cruz, CA. August 2013. Poster Presentation.

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CAMP Poster Presentation Award - University of California-Irvine, February 2014

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Summer Research Internship for Minority Students (SRIMS). Marshall University, Huntington, WV. Summer 2014

2013 Summer Research Experience, University of California-Santa Cruz, Santa Cruz, CA. Summer 2013


Athena Pasapodero

MARC Graduate-Class of 2015.

Lab Group: Dr. Barry Bowman Lab

Major: Molecular, Cell, and Developmental Biology

Research: Characterizing Calcium Transport in Neurospora crassa.

Presentations/Awards/Internships:

Cellular and Molecular Biosciences characterizing Calcium Transport Neurospora Crassa. Athena Papasodero and Dr. Barry Bowman, University of California-Santa Cruz, Santa Cruz, CA. California Alliance Minority Participation Symposium 2015. University of California-Irvine, Irvine, CA. February 2015. Poster Presentation.

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Summer Research Opportunity at UC San Diego, Summer 2014. Worked in Antonio DeMaio's Lab at UCSD.

Summer Research Institute 2013, University of California-Santa Cruz, Santa Cruz, CA. Summer 2013

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Diversity Fellowship from University of California-Irvine, Celluar and Molecular Biosciences Program. 2015

John Halverson Scholarship. University of California-Santa Cruz, Santa Cruz, CA. 2015


Rolando Cruz Perez

MARC Graduate-Class of 2015.; Transfer Student from Hartnell College

Lab Group: Professor Nadar Pourmand Lab

Major: Biomolecular Engineering with a minor in Bioinformatics

Research: In the Pourmand lab we build tools for biologists by applying engineering principles. My work involves Bioelectronics, Microfluidics, and Bio-Nano-Technology. My senior thesis delineates the innovation of a cell capture device for single cell nanosurgery of non-adherent cells.

Publication:  Metal-organic hybrid resonant terahertz absorbers with SU-8 photoresist dielectric layer.  Dragoslav Grbovic; Fabio Alves; Brian Kearney; Benjamin Waxer; Rolando Perez; George Omictin J. Micro/Nanolith. MEMS MOEMS. 12 (4), 041204 (October 22, 2013);  doi: 10.1117/1.JMM.12.4.041204

Presentations/Awards/Internships:

Cell Sifter: High-Throughput Immobilization of Non-Adherent Single Cells. Rolando Perez, Dr. Nader Pourmand. University of California-Santa Cruz, Santa Cruz, CA. 5th Annual Summer Undergraduate Research Symposium,  University of California-Santa Cruz, Santa Cruz, CA. August 2014. Poster Presentation.

Recombinant Protein Purification of mCherry. Sharon Idiga and Rolando Perez with Professor Melissa Jurica in the Summer Research Institute. University of California-Santa Cruz, Summer Research Symposium, Santa Cruz, CA. August 2013.

THz Absorbers Fabricated from an SU-8 Photoresist Dielectric Layer. Rolando Perez, George Omictim, Dr. Dragoslav Grbovic. Naval Postgraduate School, Monterey, CA. Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) National Conference 2012, Seattle, WA. October 2012. Poster Presentation. 

THz Absorbers Fabricated from an SU-8 Photoresist Dielectric Layer. Rolando Perez, George Omictim, Dr. Dragoslav Grbovic. Naval Postgraduate School, Monterey, CA. 2012 Summer Research Symposium, Hartnell Community College, Salinas, CA. August 2012. Poster Presentation.

THz Absorbers Fabricated from an SU-8 Photoresist Dielectric Layer. Rolando Perez, George Omictim, Dr. Dragoslav Grbovic. Naval Postgraduate School, Monterey, CA. 2012 Summer Research Symposium, Hartnell Community College, Salinas, CA. August 2012. Oral Presentation.

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Tau Beta Pi-Engineering Honor Society, Winter 2015

Dean's Honor Winter 2015. University of California-Santa Cruz, Santa Cruz, CA.

Dean's Honor Fall 2014. University of California-Santa Cruz, Santa Cruz, CA.

Dean's Honor Spring 2014. University of California-Santa Cruz, Santa Cruz, CA.

Dean's Honor Winter 2014. University of California-Santa Cruz, Santa Cruz, CA.

2014 UCSC iGEM Team, Captain. University of California-Santa Cruz, Santa Cruz, CA. Winter - Summer 2014

Silicon Valley Concil Scholar. Sunnyvale, CA. 2013.

2013 UCSC iGEM Team. University of California-Santa Cruz, Santa Cruz, CA. Summer 2013

Dean's Honors Fall 2013. University of California-Santa Cruz, Santa Cruz, CA.

Matsui Foundation Scholarship. Hartnell Community College, Salinas, CA. 2013-2015

All-California Academic Team, Phi Theta Kappa Honor Society. Hartnell Community College, Salinas, CA. 2013.

National Science Foundation (NSF) S-STEM Scholarship. Hartnell Community College, Salinas, CA. 2011-2012

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Summer Research Experience 2014. University of California-Santa Cruz, Santa Cruz, CA. Summer 2014

Summer Research Institute 2013. University of California-Santa Cruz, Santa Cruz, CA. Summer 2013

Community College Catalyst. Naval Postgraduate School, Monterey, CA. Summer 2012


Sofia Romero

MARC Graduate - Class of 2017

Lab Group: Barry Bowman

Major: Molecular, Cell & Developmental Biology

Research: 

Understand intracellular protein trafficking is involved in lysosome and vacuole synthesis in the haploid fungus Neurospora crassa. Newly discovered organelles that reside within the apical tip of N. crassa, classified as pre-vacuole compartments (PVCs), share similar Rab GTPase markers as late endosomes and mature vacuoles. Rab GTPases are G-proteins that regulate multiple steps of membrane trafficking, including vesicle and endosomal formation. The goal of my project is to understand the role that PVCs play in vacuolar synthesis.

Presentations/Awards/Internships:

The Characterization of Zika Virus 5’ Untranslated Region as a Regulatory Component for Translation. Sofia Romero, Sarah Gonzales-van Horn, Peter Sarnow. Tampa, FL. Annual Biomedical Research Conference for Minority Students (ABRCMS), 2016. Poster Presentation

The Characterization of Zika Virus 5’ Untranslated Region as a Regulatory Component for Translation. Sofia Romero, Sarah Gonzales-van Horn, Peter Sarnow. Standford University, Stanford, CA. Summer Research Pogram Symposium, 2016. Oral and Poster Presentation.

The Role of Rab-7 GTPase in the Biogenesis of Vacuoles. Sofia Romero and Barry Bowman. University of California, Irvine. California Alliance for Minority Participation (CAMP) Conference, 2016. Poster Presentation.

The TALLYHO mouse carries an obesity QTL, tabw3, on chromosome 1 that exaggerates high-fat diet induced obesity. Sofia Romero, Jacaline K. Parkman, and Jung Han Kim. Seattle, WA. Annual Biomedical Research Conference for Minority Students (ABRCMS), 2015. Poster Presentation.

The TALLYHO mouse carries an obesity QTL, tabw3, on chromosome 1 that exaggerates high-fat diet induced obesity. Sofia Romero, Jacaline K. Parkman, and Jung Han Kim. Washington, DC. Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) Conference, 2015. Poster Presentation 

The TALLYHO mouse carries an obesity QTL, tabw3, on chromosome 1 that exaggerates high-fat diet induced obesity. Sofia Romero, Jacaline K. Parkman, and Jung Han Kim. West Virginia IDA Network for Biomedical Research Excellence, 2015. Poster 

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2016 Annual Biomedical Research Conference for Minority Student oral presentation award

2016 Spring quarter Dean’s Honor

2016 Winter quarter Dean’s Honor

2015 Winter quarter Dean’s Honor

2015 SACNAS National Conference Travel Scholarship, Washington D.C.

2015 ABRCMS National Conference Travel Award. Seattle, Washington

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Stanford Summer Research Program 2016,

Summer Research Internship for Minority Students (2015)

California Alliance for Minority Participation in Science (CAMP) 2015

Buck Institute Research on Aging (2012)


 
 
 
 
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