Hanna Abuhay

MARC Fellow - Junior

Lab Group: Russ Corbett

Major: Neuroscience

Research:

Presentations/Awards/Internships:

Limited Proteolysis and Crystallization of Enzyme Proteinase K. Hannah Abuhay, Eloy Harris, Marcia Trochez, and Carrie Partch, University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation

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Summer Research Institute 2016, University of California-Santa Cruz. Santa Cruz, CA. Summer 2016


Yewande Alabi

MARC Fellow - Junior

Lab Group: Melissa Jurica

Major: Human Biology

Research:

Spliceosomes are tiny molecular machines found in all human cells. They help shape how our genes encode for an organism as unique and complex as a human being. The spliceosome is a large and complex ribonucleic protein (RNP) that consist of 5 small nuclear RNPs (snRNPs): U1, U2, U4, U5 and U6 that base pair with and recognize splice site sequences in pre-mRNA.   My project focuses on the pre-spliceosomal complex A. In Complex A, The U2 snRNP binds to the branch point sequence of pre-mRNA and ATP is hydrolyzed. My project aims to test the effects of ATP or ATP depletion in RNA substrates lacking core anchoring regions through native gel analysis. We hope to gather more information about the role of ATP in Complex A formation.

Presentations/Awards/Internships:

MYC Overexpression Increases U2 snRNP Variant Levels. Yewande AlabiBrian Kosmyna and Charles Query. Seattle, WA. Annual Biomedical Research Conference for Minority Students (ABRCMS), 2016. Poster Presentation

MYC Overexpression Increases U2 snRNP Variant Levels. Yewande Alabi, Brian Kosmyna, Britta Will and Charles Query. Albert Einstein College of Medicine, Einstein SURP Summer Research Symposium, 2016. Poster Presentation  

MYC Overexpression Increases U2 snRNP Variant Levels. Yewande Alabi, Brian Kosmyna, Britta Will and Charles Query. University of California, Santa Cruz, 7th Annual Physical and Biological Science Summer Research Symposium, 2016. Poster Presentation

MYC Overexpression Increases U2 snRNP Variant Levels. Yewande Alabi, Brian Kosmyna, Britta Will and Charles Query. University of California, Santa Cruz, ACE Orientation and Resource Fair, 2016. Poster Presentation

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2014 Fall Dean’s Honors

2015 Winter Dean’s Honors

2015 Spring Dean’s Honors

2015 Fall Dean’s Honors

Stevenson College Core Award

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Summer Undergraduate Research Program 2016, Albert Einstein College of Medicine, New York, NY. Summer 2016


Angel Baroz

MARC Fellow - Junior

Lab Group: Ted Holman

Major: Biochemistry and Molecular Biology

Research:

The biological function of the enzyme lipoxygenase and its role in the inflammatory response. Particularly, I utilize enzymology, molecular biology, spectroscopy and crystallography to investigate the function of human 12 lipoxygenase.

Presentations/Awards/Internships:

Inhibition of the Metallownzyme, Soybean Lipoxygenase. Angel Baroz, Jovany Cruz, Naomi Tesfuzigt, University of California, Santa Cruz, 7th Annual Physical and Biological Science Summer Research Symposium, 2016. Poster Presentation

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Summer Research Institute 2016, University of California, Santa Cruz. Santa Cruz, CA. Summer 2016


Carolina Cuellar

MARC Fellow - Junior

Lab Group: Rebecca DuBois

Major: Bioengineering

Research: 

Study the influenza A RNA polymerase through a protein inhibitor assay. Also working on crystallizing the human Astrovirus with and without an antibody to examine structure and activity of the virus.

Presentations/Awards/Internships:

Cloning of the RNA polymerase on influenza A. University of California, Irvine. California Alliance for Minority Participation (CAMP) Conference, 2017. Poster Presentation.

Improving Efficiency of Isolation of Chromosome Circles. Carolina Cuellar, Kelssie Sontay, and Grant Hartzog, University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation 

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Summer Research Institute 2016, University of California, Santa Cruz. Santa Cruz, CA. Summer 2016


Sarah Deleon

MARC Fellow - Junior

Lab Group: Fitnat Yildiz

Major: Biochemistry and Molecular Biology

Research: 

Exploring the role of the Vibrio exopolysaccharide (VPS) degradation enzyme, RbmB, in VPS production and biofilm formation in Vibrio Cholerae

Presentations/Awards/Internships:

Characterization of the Electrophysiological Properties of the Neurons in the Thalamic Reticular Nucleus. Sarah DeleonV.G. Lopez Huerta and Ayan Ghoshal., Broad Institute Summer Research Symposium, 2016. Poster and Oral Presentation. 
 
Characterization of the Electrophysiological Properties of the Neurons in the Thalamic Reticular Nucleus. Sarah DeleonV.G. Lopez Huerta and Ayan GhoshalMIT Summer Research Symposium, 2016. Poster Presentation. 
 
Characterization of the Electrophysiological Properties of the Neurons in the Thalamic Reticular Nucleus. Sarah DeleonV.G. Lopez Huerta and Ayan Ghoshal. University of California, Santa Cruz, 7th Annual Physical and Biological Science Summer Research Symposium, 2016. Poster Presentation. 
 
Characterization of the Electrophysiological Properties of the Neurons in the Thalamic Reticular Nucleus. Sarah DeleonV.G. Lopez Huerta and Ayan GhoshalUniversity of California, Santa Cruz, ACE Orientation and Resource Fair, 2016. Poster Presentation. 
 
Characterization of the Electrophysiological Properties of the Neurons in the Thalamic Reticular Nucleus. Sarah DeleonV.G. Lopez Huerta and Ayan Ghoshal. Long Beach, CA. Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) Conference, 2016. Poster Presentation. 
 
Effects of Genetically Induced Sleep Deprivation on Alzheimer's Disease-like Pathology in Drosophila. Sarah DeleonTyler Dewitt, Thomas Finn and Jeremy Lee. University of California, Santa Cruz, 19th Annual Undergraduate Research Poster Symposium, 2016. Poster Presentation.   

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2016 Cowell College Student Project Funding 

2016 Travel Scholarship Recipient for SACNAS Conference 

Fall 2014-Spring 2016 Deans Honor List
 
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Summer Research Program in Genomics at the Broad Institute of Harvard and MIT, 2016

Yongtong Lao

MARC Fellow - Senior

Lab Group: Scott Lokey

Major: Molecular, Cell & Developmental Biology

Research:

Synthetic analogs of cyclic peptide Phepropeptin as virulence blockers of human pathogens

Gram-negative pathogens cause millions of illnesses and death worldwide each year. Treatment of infections with antibiotics, which target all bacteria indistinguishably, often gives rise to resistance and destroys our healthy microbiota. Emergence of antibiotic resistance bacteria is the current issue of global public health. One promising strategy to combat the antibiotic resistant bacteria is virulence blockers, which are compounds that suppress pathogenicity without killing or inhibiting bacterial growth. Type III secretion system (T3SS), a needle-like appendage that bacteria use to inject effector proteins to the host cells to suppress host defense is an important virulence factor target for drug development. T3SS is required for virulence in dozens of Gram-negative bacteria pathogens but largely absent in nonpathogenic bacteria. We identified analogs of the natural cyclic peptide Phepropeptin that inhibit T3SS in both Yersinia and Pseudomonas through an innate immune-based high throughput screen. To further optimize the efficacy, we synthesized new analogs with improved potency. The best compound from this series inhibits 90% of toxin excretion and has an IC50 of 4 mM. These peptides did not inhibit bacterial growth and did not target flagellum, a motility system structurally similar to T3SS, indicating a specific block on the T3SS. Therefore, analogs of Phepropeptin are promising virulent blockers of several human pathogens.

Presentations/Awards/Internships:

Optimization of Novel Type III secretion inhibitors as Anti-virulence Factor. Yongtong Lao, Joshua Schwochert, Hanh Lam, Scott Lokey and Vicki Auerbuch Stone. Long Beach, CA. Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) Conference, 2016. Poster Presentation.

Synthetic analogs of cyclic peptide Phepropeptin as virulence blockers of human pathogen. Yongtong Lao, Joshua Schwochert, Joshua Schwochert, Hanh Lam, Vicki A. Stone, and Scott Lokey, University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation

Synthetic Peptoid  Analogs  of Phepropeptin  Inhibit  Bacterial  Type  III Secretion System. Yongtong Lao, Joshua Schwochert, Hanh Lam, Scott Lokey and Vicki Auerbuch Stone. University of California, Santa Cruz. Division of Physical and Biological Science and Jack Baskin Engineering 19th Annual Undergraduate Research Symposium, 2016. Poster Presentation 

Synthetic Peptoid Analogs of Phepropeptin Inhibit Bacterial Type III Secretion System. Yongtong Lao, Joshua Schwochert, Hanh Lam, Scott Lokey and Vicki Auerbuch Stone. University of California,Santa Cruz. Department of Chemistry Bunnett Research Symposium, 2016. Poster Presentaion.

1.Schwochert,  J. A.; Lao,Y.; Rye, C. R.; Naylor, M.R.; Desai, PV.; Gonzalez Valcarcel,  IC.; Barrett, JA.; Sawada, G.; Blanco, MJ and  Lokey, R.S. JAS Medicinal  Chemistry  Letters, 2016. Stereochemistry  balances cell permeability  and solubility  in thenaturally derived phepropeptin cyclic peptides. 2016  

2.Pye, R.; Hewitt, W.; Schwochert, J. A.; Haddad, T.; Townsend, C .; Etienne, L.; Lao, Y.;  Limberakis,  C.; Furukawa,  A.; Mathiowetz,  A.; Price, D.; Liras, L and Lokey, R.S. Non-Classical  Size Dependence of Permeation Defines Bounds for Passive Adsorptionof Large Drug Molecules. 2016  

Manuscript in Prep
1. Lam, H.; Schwochert, J. A; Lao, Y.; Kooner, O.; Luu, J.; Morgan, J.; Lokey, R.S and Auerbuch, V. Synthetic  Cyclic Peptomers As Type III Secretion System Inhibitors. 2017
 
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2013-2016 Dean’s honors  
 
2016 SACNAS (Advancing Chicanos/Hispanic & Native Americans in Science) Travel Scholarship 
 

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Summer Research Experience 2016, University of California, Santa Cruz. Santa Cruz, CA. Summer 2016


Erik Li

MARC Fellow - Junior

Lab Group: Jeremy Sanford

Major: Molecular, Cell & Developmental Biology

Research:

Presentations/Awards/Internships:

Investigating The Structural Properties of Plasmid DNAInvestigating The Structural Properties of Plasmid DNA. Erik Li, Francis Albert Apolinario, and Michael D. Stone. University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation.

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Summer Research Institute 2016, University of California, Santa Cruz. Santa Cruz, CA. Summer 2016


Sofia Romero

MARC Fellow - Senior

Lab Group: Barry Bowman

Major: Molecular, Cell & Developmental Biology

Research: 

Understand intracellular protein trafficking is involved in lysosome and vacuole synthesis in the haploid fungus Neurospora crassa. Newly discovered organelles that reside within the apical tip of N. crassa, classified as pre-vacuole compartments (PVCs), share similar Rab GTPase markers as late endosomes and mature vacuoles. Rab GTPases are G-proteins that regulate multiple steps of membrane trafficking, including vesicle and endosomal formation. The goal of my project is to understand the role that PVCs play in vacuolar synthesis.

Presentations/Awards/Internships:

The Characterization of Zika Virus 5’ Untranslated Region as a Regulatory Component for Translation. Sofia Romero, Sarah Gonzales-van Horn, Peter Sarnow. Tampa, FL. Annual Biomedical Research Conference for Minority Students (ABRCMS), 2016. Poster Presentation

The Characterization of Zika Virus 5’ Untranslated Region as a Regulatory Component for Translation. Sofia Romero, Sarah Gonzales-van Horn, Peter Sarnow. Standford University, Stanford, CA. Summer Research Pogram Symposium, 2016. Oral and Poster Presentation.

The Role of Rab-7 GTPase in the Biogenesis of Vacuoles. Sofia Romero and Barry Bowman. University of California, Irvine. California Alliance for Minority Participation (CAMP) Conference, 2016. Poster Presentation.

The TALLYHO mouse carries an obesity QTL, tabw3, on chromosome 1 that exaggerates high-fat diet induced obesity. Sofia Romero, Jacaline K. Parkman, and Jung Han Kim. Seattle, WA. Annual Biomedical Research Conference for Minority Students (ABRCMS), 2015. Poster Presentation.

The TALLYHO mouse carries an obesity QTL, tabw3, on chromosome 1 that exaggerates high-fat diet induced obesity. Sofia Romero, Jacaline K. Parkman, and Jung Han Kim. Washington, DC. Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) Conference, 2015. Poster Presentation 

The TALLYHO mouse carries an obesity QTL, tabw3, on chromosome 1 that exaggerates high-fat diet induced obesity. Sofia Romero, Jacaline K. Parkman, and Jung Han Kim. West Virginia IDA Network for Biomedical Research Excellence, 2015. Poster 

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2016 Annual Biomedical Research Conference for Minority Student oral presentation award

2016 Spring quarter Dean’s Honor

2016 Winter quarter Dean’s Honor

2015 Winter quarter Dean’s Honor

2015 SACNAS National Conference Travel Scholarship, Washington D.C.

2015 ABRCMS National Conference Travel Award. Seattle, Washington

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Stanford Summer Research Program 2016,

Summer Research Internship for Minority Students (2015)

California Alliance for Minority Participation in Science (CAMP) 2015

Buck Institute Research on Aging (2012)


Marcia Trochez

MARC Fellow - Junior

Lab Group: Needhi Bahlla

Major: Biochemistry and Molecular Biology

Research:

Presentations/Awards/Internships:

Limited Proteolysis and Crystallization of Enzyme Proteinase K. Marcia Trochez, Hannah Abuhay, Eloy Harris, and Carrie Partch, University of California, Santa Cruz, 7th Annual Physical and Biological Sciences Summer Research Symposium, 2016. Poster Presentation

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Summer Research Institute 2016, University of California, Santa Cruz. Santa Cruz, CA. Summer 2016


Eva Tang

MARC Fellow - Senior

Lab Group: Jeremy Sanford

Major: Molecular, Cell & Developmental Biology

Research:

Presentations/Awards/Internships:

Characterization of Cis Element in SUV420H1 with a Role in Alternation Splicing Translational Control. Eva Tang, Harmony Folse, Aishwarya Jacob, Jeremyy Sanford, University of California, Santa Cruz, 7th Annual Physical and Biological Summer Research Symposium, 2016. Poster Presentation.

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Summer Research Experience 2016, University of California, Santa Cruz. Santa Cruz, CA. Summer 2016


 
 
 
 
 
 
 
 
 
 
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