Mel Jones, UC LEADS scholar

As a cyclase, seaweed enzyme dsKabC is one of the few out of hundreds of characterized enzymes in the Non-Heme Fe2+/αKG – Dependent Dioxygenases family that have the advantage of generating a novel C-C cyclization and my aspiration is to be able to engineer a mushroom enzyme IboH to achieve the same transformation that is essential to medicinal chemistry.